The Alphabet Soup of HIV Reservoir Markers.

ABSTRACT:

Purpose of review

Despite the success of antiretroviral therapy in suppressing HIV, life-long therapy is required to avoid HIV reactivation from long-lived viral reservoirs. Currently, there is intense interest in searching for therapeutic interventions that can purge the viral reservoir to achieve complete remission in HIV patients off antiretroviral therapy. The evaluation of such interventions relies on our ability to accurately and precisely measure the true size of the viral reservoir. In this review, we assess the most commonly used HIV reservoir assays, as a clear understanding of the strengths and weaknesses of each is vital for the accurate interpretation of results and for the development of improved assays.

Recent findings

The quantification of intracellular or pl

SUBMITTER: Sharaf RR 

PROVIDER: S-EPMC5519144 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature