Unique morphological characteristics of mitochondrial subtypes in the heart: the effect of ischemia and ischemic preconditioning.

ABSTRACT:

Rationale

Three subsets of mitochondria have been described in adult cardiomyocytes - intermyofibrillar (IMF), subsarcolemmal (SSM), and perinuclear (PN). They have been shown to differ in physiology, but whether they also vary in morphological characteristics is unknown. Ischemic preconditioning (IPC) is known to prevent mitochondrial dysfunction induced by acute myocardial ischemia/reperfusion injury (IRI), but whether IPC can also modulate mitochondrial morphology is not known.

Aims

Morphological characteristics of three different subsets of adult cardiac mitochondria along with the effect of ischemia and IPC on mitochondrial morphology will be investigated.

Methods

Mouse hearts were subjected to the following treatments (N=6 for each group): stabilization only, IP

SUBMITTER: Kalkhoran SB 

PROVIDER: S-EPMC5519153 | biostudies-literature | 2017 Jan-Mar

REPOSITORIES: biostudies-literature