Association of APOE gene polymorphism with lipid profile and coronary artery disease in Afro-Caribbeans.

ABSTRACT:

Objectives

Apolipoprotein E gene (APOE) polymorphism is associated with the lipid profile and cardio-vascular disease. However, these relationships vary between ethnic groups. We evaluated, for the first time in an Afro-Caribbean population, the distribution of APOE polymorphisms and their associations with coronary artery disease (CAD), the lipid profile and other cardio-metabolic risk factors.

Methods

We studied 712 Afro-Caribbean subjects including 220 with documented CAD and 492 healthy subjects. TaqMan assays were performed to genotype rs7412 and rs429358, the two variants that determine the APOE alleles ε2, ε3 and ε4. The association between APOE genotype and the lipid profile was analysed by comparing ε2 carriers, ε3 homozygotes and ε4 carriers.

Results

The fre

SUBMITTER: Larifla L 

PROVIDER: S-EPMC5519172 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature