Enhanced insulin sensitivity in successful, long-term weight loss maintainers compared with matched controls with no weight loss history.

ABSTRACT:

Background

Weight gain is associated with deterioration in metabolic health, whereas weight loss improves insulin sensitivity. This study assesses the impact of long-term, successfully maintained weight loss and weight-loss relapse on measures of insulin sensitivity and identifies factors that explain variability in insulin sensitivity.

Methods

Women (20-45 years) were recruited into four groups: reduced-overweight/obese (RED, n=15); body mass index (BMI)-matched controls (stable low-weight, n=19), BMI⩽27 kg m^-2; relapsed-overweight/obese subjects (REL, n=11); and BMI-matched controls (obese stable weight, n=11), BMI⩾27 kg m^-2. A 75 g oral glucose tolerance test determined fasting and 2 h plasma glucose and insulin. Homeostatic Model Assessment (HOMA-IR

SUBMITTER: Clamp LD 

PROVIDER: S-EPMC5519190 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature