The iron-dependent mitochondrial superoxide dismutase SODA promotes Leishmania virulence.

ABSTRACT: Leishmaniasis is one of the leading globally neglected diseases, affecting millions of people worldwide. Leishmania infection depends on the ability of insect-transmitted metacyclic promastigotes to invade mammalian hosts, differentiate into amastigotes, and replicate inside macrophages. To counter the hostile oxidative environment inside macrophages, these protozoans contain anti-oxidant systems that include iron-dependent superoxide dismutases (SODs) in mitochondria and glycosomes. Increasing evidence suggests that in addition to this protective role, Leishmania mitochondrial SOD may also initiate H₂O₂-mediated redox signaling that regulates gene expression and metabolic changes associated with differentiation into virulent forms. To investigate this h

SUBMITTER: Mittra B 

PROVIDER: S-EPMC5519379 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature