Region of interest correction factors improve reliability of diffusion imaging measures within and across scanners and field strengths.

ABSTRACT: Diffusion tensor imaging (DTI) measures are commonly used as imaging markers to investigate individual differences in relation to behavioral and health-related characteristics. However, the ability to detect reliable associations in cross-sectional or longitudinal studies is limited by the reliability of the diffusion measures. Several studies have examined the reliability of diffusion measures within (i.e. intra-site) and across (i.e. inter-site) scanners with mixed results. Our study compares the test-retest reliability of diffusion measures within and across scanners and field strengths in cognitively normal older adults with a follow-up interval less than 2.25 years. Intra-class correlation (ICC) and coefficient of variation (CoV) of fractional anisotropy (FA) and mean diffusivity (MD)

SUBMITTER: Venkatraman VK 

PROVIDER: S-EPMC5519407 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature