Cytomegalovirus-Responsive CD8⁺ T Cells Expand After Solid Organ Transplantation in the Absence of CMV Disease.

ABSTRACT: Cytomegalovirus (CMV) is a major cause of morbidity and mortality in solid organ transplant recipients. Approximately 60% of adults are CMV seropositive, indicating previous exposure. Following resolution of the primary infection, CMV remains in a latent state. Reactivation is controlled by memory T cells in healthy individuals; transplant recipients have reduced memory T cell function due to chronic immunosuppressive therapies. In this study, CD8⁺ T cell responses to CMV polypeptides immediate-early-1 and pp65 were analyzed in 16 CMV-seropositive kidney and heart transplant recipients longitudinally pretransplantation and posttransplantation. All patients received standard of care maintenance immunosuppression, antiviral prophylaxis, and CMV viral load monitoring, with approxim

SUBMITTER: Higdon LE 

PROVIDER: S-EPMC5519416 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature