Therapeutic effect of human ghrelin and growth hormone: Attenuation of immunosuppression in septic aged rats.

ABSTRACT: Sepsis is a leading cause of mortality in intensive care units, and is more common in the geriatric population. The control of hyperinflammation has been suggested as a therapeutic approach in sepsis, but to date clinical trials utilizing this strategy have not lead to an effective treatment. In addition to hyperinflammation, patients with sepsis often experience a state of immunosuppression, which serves as an important determinant for increased morbidity and mortality. We previously used aged animals to demonstrate the effectiveness of combined treatment with human ghrelin (Ghr) and human growth hormone (GH) in improving organ injury and survival in septic animals. Here, we hypothesized that combined treatment with Ghr and GH could improve immune function in septic aged animals. Male 24-

SUBMITTER: Zhou M 

PROVIDER: S-EPMC5519455 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature