Protein synthesis is associated with high-speed dynamics and broad-band stability of functional hubs in the brain.

ABSTRACT: L-[1-¹¹C]leucine PET can be used to measure in vivo protein synthesis in the brain. However, the relationship between regional protein synthesis and on-going neural dynamics is unclear. We use a graph theoretical approach to examine the relationship between cerebral protein synthesis (rCPS) and both static and dynamical measures of functional connectivity (measured using resting state functional MRI, R-fMRI). Our graph theoretical analysis demonstrates a significant positive relationship between protein turnover and static measures of functional connectivity. We compared these results to simple measures of metabolism in the cortex using [¹⁸F]FDG PET). Whilst some relationships between [¹⁸F]FDG binding and graph theoretical measures was present, there remain

SUBMITTER: Hellyer PJ 

PROVIDER: S-EPMC5519503 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature