The feoABC Locus of Yersinia pestis Likely Has Two Promoters Causing Unique Iron Regulation.

ABSTRACT: The FeoABC ferrous transporter is a wide-spread bacterial system. While the feoABC locus is regulated by a number of factors in the bacteria studied, we have previously found that regulation of feoABC in Yersinia pestis appears to be unique. None of the non-iron responsive transcriptional regulators that control expression of feoABC in other bacteria do so in Y. pestis. Another unique factor is the iron and Fur regulation of the Y. pestis feoABC locus occurs during microaerobic but not aerobic growth. Here we show that this unique iron-regulation is not due to a unique aspect of the Y. pestis Fur protein but to DNA sequences that regulate transcription. We have used truncations, alterations, and deletions of the feoA::lacZ reporter to

SUBMITTER: O'Connor L 

PROVIDER: S-EPMC5519574 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature