Genotype-environment interaction on human cognitive function conditioned on the status of breastfeeding and maternal smoking around birth.

ABSTRACT: We estimated genotype by environment interaction (G × E) on later cognitive performance and educational attainment across four unique environments, i.e. 1) breastfed without maternal smoking, 2) breastfed with maternal smoking, 3) non-breastfed without maternal smoking and 4) non-breastfed with maternal smoking, using a novel design and statistical approach that was facilitated by the availability of datasets with the genome-wide single nucleotide polymorphisms (SNPs). There was significant G × E for both fluid intelligence (p-value = 1.0E-03) and educational attainment (p-value = 8.3E-05) when comparing genetic effects in the group of individuals who were breastfed without maternal smoking with those not breastfed without maternal smoking. There was also significant G × E for fluid intell

SUBMITTER: Lee SH 

PROVIDER: S-EPMC5519601 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature