Effects of cardiac timing and peripheral resistance on measurement of pulse wave velocity for assessment of arterial stiffness.

ABSTRACT: To investigate the effects of heart rate (HR), left ventricular ejection time (LVET) and wave reflection on arterial stiffness as assessed by pulse wave velocity (PWV), a pulse wave propagation simulation system (PWPSim) based on the transmission line model of the arterial tree was developed and was applied to investigate pulse wave propagation. HR, LVET, arterial elastic modulus and peripheral resistance were increased from 60 to 100 beats per minute (bpm), 0.1 to 0.45 seconds, 0.5 to 1.5 times and 0.5 to 1.5 times of the normal value, respectively. Carotid-femoral PWV (cfPWV) and brachial-ankle PWV (baPWV) were calculated by intersecting tangent method (cfPWV_tan and baPWV_tan), maximum slope (cfPWV_max and baPWV_max), and using the Moens-Korteweg

SUBMITTER: Xiao H 

PROVIDER: S-EPMC5519778 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature