Microbes Are Associated with Host Innate Immune Response in Idiopathic Pulmonary Fibrosis.

ABSTRACT:

Rationale

Differences in the lung microbial community influence idiopathic pulmonary fibrosis (IPF) progression. Whether the lung microbiome influences IPF host defense remains unknown.

Objectives

To explore the host immune response and microbial interaction in IPF as they relate to progression-free survival (PFS), fibroblast function, and leukocyte phenotypes.

Methods

Paired microarray gene expression data derived from peripheral blood mononuclear cells as well as 16S ribosomal RNA sequencing data from bronchoalveolar lavage obtained as part of the COMET-IPF (Correlating Outcomes with Biochemical Markers to Estimate Time-Progression in Idiopathic Pulmonary Fibrosis) study were used to conduct association pathway analyses. The responsiveness of paired lung fibroblasts

SUBMITTER: Huang Y 

PROVIDER: S-EPMC5519968 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature