Ontology highlight
ABSTRACT:
SUBMITTER: Langefeld CD
PROVIDER: S-EPMC5520018 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Nature communications 20170717
Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and ethnic disparities. We report a large transancestral association study of SLE using Immunochip genotype data from 27,574 individuals of European (EA), African (AA) and Hispanic Amerindian (HA) ancestry. We identify 58 distinct non-HLA regions in EA, 9 in AA and 16 in HA (∼50% of these regions have multiple independent associations); these include 24 novel SLE regions (P<5 × 10<sup>-8</sup>), refined association si ...[more]