Microbial shifts and signatures of long-term remission in ulcerative colitis after faecal microbiota transplantation.

ABSTRACT: Faecal microbiota transplantation (FMT) may contribute towards disease remission in ulcerative colitis (UC), but it is unknown which factors determine long-term effect of treatment. Here, we aimed to identify bacterial signatures associated with sustained remission. To this end, samples from healthy donors and UC patients-grouped into responders and non-responders at a primary end point (week 12) and further stratified by sustained clinical remission and relapse assessed at ⩾1-year follow-up were analysed, comparing the efficacy of FMT from either a healthy donor or autologous faeces. Microbiota composition was determined with a 16S rRNA gene-based phylogenetic microarray on faecal and mucosal samples, and functional profiles were predicted using PICRUSt with quantitative PCR verification

SUBMITTER: Fuentes S 

PROVIDER: S-EPMC5520032 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature