Ontology highlight
ABSTRACT:
SUBMITTER: Machutta CA
PROVIDER: S-EPMC5520047 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Nature communications 20170717
The identification and prioritization of chemically tractable therapeutic targets is a significant challenge in the discovery of new medicines. We have developed a novel method that rapidly screens multiple proteins in parallel using DNA-encoded library technology (ELT). Initial efforts were focused on the efficient discovery of antibacterial leads against 119 targets from Acinetobacter baumannii and Staphylococcus aureus. The success of this effort led to the hypothesis that the relative number ...[more]