Expanded carrier screening: what determines intended participation and can this be influenced by message framing and narrative information?

ABSTRACT: Next-generation sequencing enabled us to create a population-based expanded carrier screening (ECS) test that simultaneously tests for 50 serious autosomal recessive diseases. Before offering this test universally, we wanted to know what factors are related to intended participation and how the general public can be informed about the test without being influenced in their intention to participate. We studied this by measuring to what extent 'message framing' and 'narrative information' can influence people's intended participation. Data were collected by means of an online survey of 504 potential users, and the factors examined were based on the Theory of Planned Behaviour and on previous research on intended participation in preconception carrier screening. Message framing was manipulate

SUBMITTER: Voorwinden JS 

PROVIDER: S-EPMC5520082 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature