Prospective study of DNA methylation at chromosome 8q24 in peripheral blood and prostate cancer risk.

ABSTRACT:

Background

Chromosome 8q24 has emerged as an important genetic susceptibility region for several cancers, including prostate cancer; however, little is known about the contribution of DNA methylation in this region to risk.

Methods

We prospectively evaluated DNA methylation at 8q24 in relation to prostate cancer using pre-diagnostic blood samples from 694 prostate cancer cases (including 172 aggressive cases) and 703 controls in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. We used logistic regression to estimate odds ratios and 95% confidence intervals.

Results

Although none remained significant after adjustment for multiple testing (q>0.05), of the 50 CpG sites meeting quality control, we identified 8 sites that were nominally associated with pr

SUBMITTER: Barry KH 

PROVIDER: S-EPMC5520085 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature