Hedgehog signalling pathway orchestrates angiogenesis in triple-negative breast cancers.

ABSTRACT:

Background

Several evidences suggest a marked angiogenic dependency in triple-negative breast cancer (TNBC) tumorigenesis and a potential sensitivity to anti-angiogenic agents. Herein, the putative role of Hedgehog (Hh) pathway in regulating TNBC-dependent angiogenesis was investigated.

Methods

Expression and regulation of the Hh pathway transcription factor glioma-associated oncogene homolog1 protein (GLI1) were studied on the endothelial compartment and on TNBC-initiated angiogenesis. To evaluate the translational relevance of our findings, the combination of paclitaxel with the Smo inhibitor NVP-LDE225 was tested in TNBC xenografted mice.

Results

Tissue microarray analysis on 200 TNBC patients showed GLI1 overexpression paired with vascular endothelial growth facto

SUBMITTER: Di Mauro C 

PROVIDER: S-EPMC5520095 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature