X-linkage is not a general inhibitor of tissue-specific gene expression in Drosophila melanogaster.

ABSTRACT: As a consequence of its difference in copy number between males and females, the X chromosome is subject to unique evolutionary forces and gene regulatory mechanisms. Previous studies of Drosophila melanogaster have shown that the expression of X-linked, testis-specific reporter genes is suppressed in the male germline. However, it is not known whether this phenomenon is restricted to testis-expressed genes or if it is a more general property of genes with tissue-specific expression, which are also underrepresented on the X chromosome. To test this, we compared the expression of three tissue-specific reporter genes (ovary, accessory gland and Malpighian tubule) inserted at various autosomal and X-chromosomal locations. In contrast to testis-specific reporter genes, we found no reduction of

SUBMITTER: Argyridou E 

PROVIDER: S-EPMC5520135 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature