Inhibition of autophagy prevents cadmium-induced prostate carcinogenesis.

ABSTRACT:

Background

Cadmium, an established carcinogen, is a risk factor for prostate cancer. Induction of autophagy is a prerequisite for cadmium-induced transformation and metastasis. The ability of Psoralidin (Pso), a non-toxic, orally bioavailable compound to inhibit cadmium-induced autophagy to prevent prostate cancer was investigated.

Methods

Psoralidin was studied using cadmium-transformed prostate epithelial cells (CTPE), which exhibit high proliferative, invasive and colony forming abilities. Gene and protein expression were evaluated by qPCR, western blot, immunohistochemistry and immunofluorescence. Xenograft models were used to study the chemopreventive effects in vivo.

Results

Cadmium-transformed prostate epithelial cells were treated with Pso resulting in growth

SUBMITTER: Pal D 

PROVIDER: S-EPMC5520206 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature