Genetic variants affecting cross-sectional lung function in adults show little or no effect on longitudinal lung function decline.

ABSTRACT:

Background

Genome-wide association studies have identified numerous genetic regions that influence cross-sectional lung function. Longitudinal decline in lung function also includes a heritable component but the genetic determinants have yet to be defined.

Objectives

We aimed to determine whether regions associated with cross-sectional lung function were also associated with longitudinal decline and to seek novel variants which influence decline.

Methods

We analysed genome-wide data from 4167 individuals from the Busselton Health Study cohort, who had undergone spirometry (12 695 observations across eight time points). A mixed model was fitted and weighted risk scores were calculated for the joint effect of 26 known regions on baseline and longitudinal changes in FEV<

SUBMITTER: John C 

PROVIDER: S-EPMC5520280 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature