KIF15 promotes pancreatic cancer proliferation via the MEK-ERK signalling pathway.

ABSTRACT:

Background

Pancreatic cancer is highly malignant and characterised by rapid and uncontrolled growth. While some of the important regulatory networks involved in pancreatic cancer have been determined, the cancer relevant genes have not been fully identified.

Methods

We screened genes that may control proliferation in pancreatic cancer in seven pairs of matched pancreatic cancer and normal pancreatic tissue samples. We examined KIF15 expression in pancreatic cancer tissues and the effect of KIF15 on cell proliferation in vitro and in vivo. The mechanisms underlying KIF15 promotion of cell proliferation were investigated.

Results

mRNA microarray and functional analysis identified 22 genes that potentially play an important role in the proliferation of pancreatic cancer.

SUBMITTER: Wang J 

PROVIDER: S-EPMC5520515 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature