Pharmacologically directed strategies in academic anticancer drug discovery based on the European NCI compounds initiative.

ABSTRACT:

Background

The European NCI compounds programme, a joint initiative of the EORTC Research Branch, Cancer Research Campaign and the US National Cancer Institute, was initiated in 1993. The objective was to help the NCI in reducing the backlog of in vivo testing of potential anticancer compounds, synthesised in Europe that emerged from the NCI in vitro 60-cell screen.

Methods

Over a period of more than twenty years the EORTC-Cancer Research Campaign panel reviewed ∼2000 compounds of which 95 were selected for further evaluation. Selected compounds were stepwise developed with clear go/no go decision points using a pharmacologically directed programme.

Results

This approach eliminated quickly compounds with unsuitable pharmacological properties. A few compounds went into

SUBMITTER: Hendriks HR 

PROVIDER: S-EPMC5520516 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature