Arterial Stiffening With Exercise in Patients With Heart Failure and Preserved Ejection Fraction.

ABSTRACT:

Background

Aortic stiffening and reduced nitric oxide (NO) availability may contribute to the pathophysiology of heart failure with preserved ejection fraction (HFpEF).

Objectives

This study compared indices of arterial stiffness at rest and during exercise in subjects with HFpEF and hypertensive control subjects to examine their relationships to cardiac hemodynamics and determine whether exertional arterial stiffening can be mitigated by inorganic nitrite.

Methods

A total of 22 hypertensive control subjects and 98 HFpEF subjects underwent hemodynamic exercise testing with simultaneous expired gas analysis to measure oxygen consumption. Invasively measured radial artery pressure waveforms were converted to central aortic waveforms by transfer function to assess integr

SUBMITTER: Reddy YNV 

PROVIDER: S-EPMC5520668 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature