NMI inhibits cancer stem cell traits by downregulating hTERT in breast cancer.

ABSTRACT: N-myc and STAT interactor (NMI) has been proved to bind to different transcription factors to regulate a variety of signaling mechanisms including DNA damage, cell cycle and epithelial-mesenchymal transition. However, the role of NMI in the regulation of cancer stem cells (CSCs) remains poorly understood. In this study, we investigated the regulation of NMI on CSCs traits in breast cancer and uncovered the underlying molecular mechanisms. We found that NMI was lowly expressed in breast cancer stem cells (BCSCs)-enriched populations. Knockdown of NMI promoted CSCs traits while its overexpression inhibited CSCs traits, including the expression of CSC-related markers, the number of CD44⁺CD24^- cell populations and the ability of mammospheres formation. We also found that

SUBMITTER: Feng X 

PROVIDER: S-EPMC5520720 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature