Survivin, a key player in cancer progression, increases in obesity and protects adipose tissue stem cells from apoptosis.

ABSTRACT: Adipose tissue (AT) has a central role in obesity-related metabolic imbalance through the dysregulated production of cytokines and adipokines. In addition to its known risk for cardiovascular disease and diabetes, obesity is also a major risk for cancer. We investigated the impact of obesity for the expression of survivin, an antiapoptotic protein upregulated by adipokines and a diagnostic biomarker of tumor onset and recurrence. In a cross-sectional study of 111 subjects classified by body mass index, circulating levels of survivin and gene expression in subcutaneous AT were significantly higher in obese patients and positively correlated with leptin. Within AT, survivin was primarily detected in human adipocyte-derived stem cells (hASCs), the adipocyte precursors that determine AT expans

SUBMITTER: Ejarque M 

PROVIDER: S-EPMC5520726 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature