6-month aortic valve implantation of an off-the-shelf tissue-engineered valve in sheep.

ABSTRACT: Diseased aortic valves often require replacement, with over 30% of the current aortic valve surgeries performed in patients who will outlive a bioprosthetic valve. While many promising tissue-engineered valves have been created in the lab using the cell-seeded polymeric scaffold paradigm, none have been successfully tested long-term in the aortic position of a pre-clinical model. The high pressure gradients and dynamic flow across the aortic valve leaflets require engineering a tissue that has the strength and compliance to withstand high mechanical demand without compromising normal hemodynamics. A long-term preclinical evaluation of an off-the-shelf tissue-engineered aortic valve in the sheep model is presented here. The valves were made from a tube of decellularized cell-produced matrix

SUBMITTER: Syedain Z 

PROVIDER: S-EPMC5520964 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature