Gene expression patterns of chicken neuregulin 3 in association with copy number variation and frameshift deletion.

ABSTRACT:

Background

Neuregulin 3 (NRG3) plays a key role in central nervous system development and is a strong candidate for human mental disorders. Thus, genetic variation in NRG3 may have some impact on a variety of phenotypes in non-mammalian vertebrates. Recently, genome-wide screening for short insertions and deletions in chicken (Gallus gallus) genomes has provided useful information about structural variation in functionally important genes. NRG3 is one such gene that has a putative frameshift deletion in exon 2, resulting in premature termination of translation. Our aims were to characterize the structure of chicken NRG3 and to compare expression patterns between NRG3 isoforms.

Results

Depending on the presence or absence of the 2-bp deletion in chicken NRG3, 3 breeds (red ju

SUBMITTER: Abe H 

PROVIDER: S-EPMC5521077 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature