Sexually divergent induction of microglial-associated neuroinflammation with hippocampal aging.

ABSTRACT:

Background

The necessity of including both males and females in molecular neuroscience research is now well understood. However, there is relatively limited basic biological data on brain sex differences across the lifespan despite the differences in age-related neurological dysfunction and disease between males and females.

Methods

Whole genome gene expression of young (3 months), adult (12 months), and old (24 months) male and female C57BL6 mice hippocampus was analyzed. Subsequent bioinformatic analyses and confirmations of age-related changes and sex differences in hippocampal gene and protein expression were performed.

Results

Males and females demonstrate both common expression changes with aging and marked sex differences in the nature and magnitude of the agin

SUBMITTER: Mangold CA 

PROVIDER: S-EPMC5521082 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature