Regulating Stem Cell Secretome Using Injectable Hydrogels with In Situ Network Formation.

ABSTRACT: A family of shear-thinning hydrogels for injectable encapsulation and long-term delivery (SHIELD) has been designed and synthesized with controlled in situ stiffening properties to regulate the stem cell secretome. The authors demonstrate that SHIELD with an intermediate stiffness (200-400 Pa) could significantly promote the angiogenic potential of human adipose-derived stem cells.

SUBMITTER: Cai L 

PROVIDER: S-EPMC5521188 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature