The prognostic impact of human papillomavirus status following treatment failure in oropharyngeal cancer.

ABSTRACT:

Introduction

Despite the human papillomavirus conferring a better prognosis in the primary treatment setting, the prognostic impact of viral status after treatment failure in oropharyngeal squamous cell carcinoma patients is poorly understood.

Methods

We retrospectively identified 33 oropharyngeal squamous cell carcinoma (OPC) patients with local and/or distant disease recurrence post-treatment, and looked at metastatic patterns, time to failure and survival patterns by HPV status.

Results

Median overall survival following local failure was not significantly different by HPV status (17 months for HPV+ vs. 14 months for HPV-, p = 0.23). However, following distant failures, HPV+ patients lived significantly longer than HPV- patients (median 42 months vs. 11 months, p =

SUBMITTER: Dave E 

PROVIDER: S-EPMC5521776 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature