Breast tissue ablation with irreversible electroporation in rabbits: A safety and feasibility study.

ABSTRACT:

Background and aim

Irreversible electroporation (IRE) was confirmed to control several solid tumors effectively in vivo. Our preclinical study aimed to assess the feasibility and safety of IRE in the breast of rabbit.

Methods

Thirty New Zealand white rabbits were randomly divided into 3 groups of 10 rabbits (control group, IRE group A, and B). Two mono-electrode needles were inserted into the breast tissue by percutaneous puncture. Electrocardiogram and vital signs were monitored before, during, and after ablation. Histopathology, immunohistochemistry, and transmission electron microscopy were examined at 0 hours, 12 hours, 24 hours, 4 days, 7 days, 14 days, and 28 days after ablation.

Results

All the rabbits survived the procedure with no significant adverse effects.

SUBMITTER: Zhang W 

PROVIDER: S-EPMC5521795 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature