EINCR1 is an EGF inducible lincRNA overexpressed in lung adenocarcinomas.

ABSTRACT: Long non-coding RNAs are being increasingly recognised as important molecules involved in regulating a diverse array of biological functions. For example, many long non-coding RNAs have been associated with tumourigenesis and in this context their molecular functions often involves impacting on chromatin and transcriptional control processes. One important cellular control system that is often deregulated in cancer cells is the ERK MAP kinase pathway. Here we have investigated whether ERK pathway signaling in response to EGF stimulation, leads to changes in the production of long non-coding RNAs. We identify several different classes of EGF pathway-regulated lncRNAs. We focus on one of the inducible lincRNAs, EGF inducible long intergenic non-coding RNA 1 (EINCR1). EINCR1 is predominantly

SUBMITTER: Nowicki-Osuch K 

PROVIDER: S-EPMC5521836 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature