APOL1 risk alleles among individuals with CKD in Northern Tanzania: A pilot study.

ABSTRACT:

Introduction

In sub-Saharan Africa, approximately 100 million people have CKD, yet genetic risk factors are not well-understood. Despite the potential importance of understanding APOL1 risk allele status among individuals with CKD, little genetic research has been conducted. Therefore, we conducted a pilot study evaluating the feasibility of and willingness to participate in genetic research on kidney disease, and we estimated APOL1 risk allele frequencies among individuals with CKD.

Methods

In 2014, we conducted a community-based field study evaluating CKD epidemiology in northern Tanzania. We assessed for CKD using urine albumin and serum creatinine to estimate GFR. We invited participants with CKD to enroll in an additional genetic study. We obtained dried-blood spots on

SUBMITTER: Stanifer JW 

PROVIDER: S-EPMC5521837 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature