Hypothalamic Ventromedial Lin28a Enhances Glucose Metabolism in Diet-Induced Obesity.

ABSTRACT: The Lin28a/Let-7 axis has been studied in peripheral tissues for its role in metabolism regulation. However, its central function remains unclear. Here we found that Lin28a is highly expressed in the hypothalamus compared with peripheral tissues. Its expression is positively correlated with positive energy balance, suggesting a potential central role for Lin28a in metabolism regulation. Thus, we targeted the hypothalamic ventromedial nucleus (VMH) to selectively overexpress (Lin28aKI^VMH ) or downregulate (Lin28aKD^VMH ) Lin28a expression in mice. With mice on a standard chow diet, body weight and glucose homeostasis were not affected in Lin28aKI^VMH or Lin28aKD^VMH mice. On a high-fat diet, although no differences

SUBMITTER: Kim JD 

PROVIDER: S-EPMC5521863 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature