Radiomanganese PET Detects Changes in Functional β-Cell Mass in Mouse Models of Diabetes.

ABSTRACT: The noninvasive measurement of functional β-cell mass would be clinically valuable for monitoring the progression of type 1 and type 2 diabetes as well as the viability of transplanted insulin-producing cells. Although previous work using MRI has shown promise for functional β-cell mass determination through voltage-dependent Ca²⁺ channel (VDCC)-mediated internalization of Mn²⁺, the clinical utility of this technique is limited by the cytotoxic levels of the Mn²⁺ contrast agent. Here, we show that positron emission tomography (PET) is advantageous for determining functional β-cell mass using ⁵²Mn²⁺ (t_1/2: 5.6 days). We investigated the whole-body distribution of ⁵²Mn²⁺ in healthy adult mice by dy

SUBMITTER: Hernandez R 

PROVIDER: S-EPMC5521871 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature