Bioinformatics analysis to identify the critical genes, microRNAs and long noncoding RNAs in melanoma.

ABSTRACT: Melanoma, which is usually induced by ultraviolet light exposure and the following DNA damage, is the most dangerous skin cancer. The purpose of the present study was to screen key molecules involved in melanoma.Microarray data of E-MTAB-1862 were downloaded from the ArrayExpress database, which included 21 primary melanoma samples and 11 benign nevus samples. In addition, the RNASeq version 2 and microRNA (miRNA) sequencing data of cutaneous melanoma were downloaded from The Cancer Genome Atlas database. After identifying the differentially expressed genes (DEGs) using Limma package, enrichment analysis and protein-protein interaction (PPI) network analysis were performed separately for them using DAVID software and Cytoscape software. In addition, survival analysis and regulatory network

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC5521900 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature