The diagnostic value of assays for circulating tumor cells in hepatocellular carcinoma: A meta-analysis.

ABSTRACT:

Purpose

Circulating tumor cells (CTCs) are considered potential biomarkers for the detection of hepatocellular carcinoma (HCC). Many studies have attempted to explore this role, but the results are variable. We conducted the first comprehensive meta-analysis to evaluate the diagnostic value of CTC assay for HCC patients. Additional prognostic value was also assessed.

Experimental design

All articles included in our study were assessed using QUADAS guidelines after a literature search. Using bivariate generalized linear mixed model and random-effects model, effect measures such as pooled sensitivity/specificity, positive likelihood ratios/negative likelihood ratios (NLRs), diagnostic odds ratios, hazard ratios (HRs), risk ratios, and corresponding 95% confidence intervals (95

SUBMITTER: Sun C 

PROVIDER: S-EPMC5521903 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature