Association of Glycemic Status During Progression of Chronic Kidney Disease With Early Dialysis Mortality in Patients With Diabetes.

ABSTRACT:

Objective

Although early trials suggested that intensive glycemic targets reduce the number of complications with diabetes, contemporary trials indicate no cardiovascular benefit and potentially higher mortality risk. As patients with advanced chronic kidney disease (CKD) transitioning to treatment with dialysis were excluded from these studies, the optimal glycemic level in this population remains uncertain. We hypothesized that glycemic status, defined by hemoglobin A_1c (HbA--_1c) and random glucose levels, in the pre-end-stage renal disease (ESRD) period is associated with higher 1-year post-ESRD mortality among patients with incident diabetes who have ESRD.

Research design and methods

Among 17,819 U.S. veterans with diabetic CKD transitioning to dial

SUBMITTER: Rhee CM 

PROVIDER: S-EPMC5521972 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature