Risk of Severe Hypoglycemia in Type 1 Diabetes Over 30 Years of Follow-up in the DCCT/EDIC Study.

ABSTRACT:

Objective

During the Diabetes Control and Complications Trial (DCCT), intensive diabetes therapy achieving a mean HbA_1c of ∼7% was associated with a threefold increase in the rate of severe hypoglycemia (defined as requiring assistance) compared with conventional diabetes therapy with a mean HbA_1c of 9% (61.2 vs. 18.7 per 100 patient-years). After ∼30 years of follow-up, we investigated the rates of severe hypoglycemia in the DCCT/Epidemiology of Diabetes Inverventions and Complications (EDIC) cohort.

Research design and methods

Rates of severe hypoglycemia were reported quarterly during DCCT and annually during EDIC (i.e., patient recall of episodes in the preceding 3 months). Risk factors influencing the rate of severe hypoglycemia over time were inve

SUBMITTER: Gubitosi-Klug RA 

PROVIDER: S-EPMC5521975 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature