A feasibility study of returning clinically actionable somatic genomic alterations identified in a research laboratory.

ABSTRACT:

Purpose

Molecular profiling performed in the research setting usually does not benefit the patients that donate their tissues. Through a prospective protocol, we sought to determine the feasibility and utility of performing broad genomic testing in the research laboratory for discovery, and the utility of giving treating physicians access to research data, with the option of validating actionable alterations in the CLIA environment.

Experimental design

1200 patients with advanced cancer underwent characterization of their tumors with high depth hybrid capture sequencing of 201 genes in the research setting. Tumors were also tested in the CLIA laboratory, with a standardized hotspot mutation analysis on an 11, 46 or 50 gene platform.

Results

527 patients (44%) had at l

SUBMITTER: Arango NP 

PROVIDER: S-EPMC5522029 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature