IK channel activation increases tumor growth and induces differential behavioral responses in two breast epithelial cell lines.

ABSTRACT: Many potassium channel families are over-expressed in cancer, but their mechanistic role in disease progression is poorly understood. Potassium channels modulate membrane potential (Vmem) and thereby influence calcium ion dynamics and other voltage-sensitive signaling mechanisms, potentially acting as transcriptional regulators. This study investigated the differential response to over-expression and activation of a cancer-associated potassium channel, the intermediate conductance calcium-activated potassium channel (IK), on aggressive behaviors in mammary epithelial and breast cancer cell lines. IK was over-expressed in the highly metastatic breast cancer cell line MDA-MB-231 and the spontaneously immortalized breast epithelial cell line MCF-10A, and the effect on cancer-associated behavi

SUBMITTER: Thurber AE 

PROVIDER: S-EPMC5522074 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature