Local recurrences at the anastomotic area are clonally related to the primary tumor in sporadic colorectal carcinoma.

ABSTRACT:

Purpose

Anastomotic recurrences (AR) occur in 2-10% of colorectal carcinoma cases after resection of primary tumor (PT). Currently, there are no molecular data investigating their genetic profile and multiple theories exist about their pathogenesis. The aim of our study was to compare the genomic profile of AR to that of the patients' corresponding matched PT and, when available, to a distant metastasis (DM).

Experimental design

Thirty-six tumors from 14 patients were genotyped using a capture-based, next-generation assay to define the mutational status of 341 cancer-associated genes. All patients had R0 resection of their PT and AR occurred 1.1-7.0 years following PT resection. A DM or a second AR was analyzed in 8 patients. All tumors were microsatellite stable except in o

SUBMITTER: Vakiani E 

PROVIDER: S-EPMC5522082 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature