Transcriptional response profiles of paired tumor-normal samples offer novel perspectives in pan-cancer analysis.

ABSTRACT: Both tumor and adjacent normal tissues are valuable in cancer research. Transcriptional response profiles represent the changes of gene expression levels between paired tumor and adjacent normal tissues. In this study, we performed a pan-cancer analysis based on the transcriptional response profiles from 633 samples across 13 cancer types. We obtained two interesting results. Using consensus clustering method, we characterized ten clusters with distinct transcriptional response patterns and enriched pathways. Notably, head and neck squamous cell carcinoma was divided in two subtypes, enriched in cell cycle-related pathways and cell adhesion-related pathways respectively. The other interesting result is that we identified 92 potential pan-cancer genes that were consistently upregulated acro

SUBMITTER: Hu S 

PROVIDER: S-EPMC5522216 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature