Effects of Sex and Education on Cognitive Change Over a 27-Year Period in Older Adults: The Rancho Bernardo Study.

ABSTRACT:

Objective

This study investigated how cognitive function changes with age and whether rates of decline vary by sex or education in a large, homogenous longitudinal cohort characterized by high participation rates, long duration of follow-up, and minimal loss to follow-up.

Design/setting/participants

Between 1988 and 2016, 2,225 community-dwelling participants of the Rancho Bernardo Study, aged 31 to 99 years at their initial cognitive assessment, completed neuropsychological testing approximately every 4 years, over a maximum 27-year follow-up.

Measurements

Linear mixed effects regression models defined sex-specific cognitive trajectories, adjusting for education and retest effects.

Results

Significant decline across all cognitive domains began around age 65 ye

SUBMITTER: Reas ET 

PROVIDER: S-EPMC5522346 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature