Solute carriers affect Anopheles stephensi survival and Plasmodium berghei infection in the salivary glands.

ABSTRACT: Malaria is caused by mosquito-borne Plasmodium spp. parasites that must infect and survive within mosquito salivary glands (SGs) prior to host transmission. Recent advances in transcriptomics and the complete genome sequencing of mosquito vectors have increased our knowledge of the SG genes and proteins involved in pathogen infection and transmission. Membrane solute carriers are key proteins involved in drug transport and are useful in the development of new interventions for transmission blocking. Herein, we applied transcriptomics analysis to compare SGs mRNA levels in Anopheles stephensi fed on non-infected and P. berghei-infected mice. The A. stephensi solute carriers prestinA and NDAE1 were up-regulated in response to infection. These molecules are predicted to interact with each oth

SUBMITTER: Couto J 

PROVIDER: S-EPMC5522484 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature