EGFR and RB1 as Dual Biomarkers in HPV-Negative Head and Neck Cancer.

ABSTRACT: Clinical decision making for human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC) is predominantly guided by disease stage and anatomic location, with few validated biomarkers. The epidermal growth factor receptor (EGFR) is an important therapeutic target, but its value in guiding therapeutic decision making remains ambiguous. We integrated analysis of clinically annotated tissue microarrays with analysis of data available through the TCGA, to investigate the idea that expression signatures involving EGFR, proteins regulating EGFR function, and core cell-cycle modulators might serve as prognostic or drug response-predictive biomarkers. This work suggests that consideration of the expression of NSDHL and proteins that regulate EGFR recycling in combination with

SUBMITTER: Beck TN 

PROVIDER: S-EPMC5522587 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature