Genome-wide mapping of transcriptional enhancer candidates using DNA and chromatin features in maize.

ABSTRACT:

Background

While most cells in multicellular organisms carry the same genetic information, in each cell type only a subset of genes is being transcribed. Such differentiation in gene expression depends, for a large part, on the activation and repression of regulatory sequences, including transcriptional enhancers. Transcriptional enhancers can be located tens of kilobases from their target genes, but display characteristic chromatin and DNA features, allowing their identification by genome-wide profiling. Here we show that integration of chromatin characteristics can be applied to predict distal enhancer candidates in Zea mays, thereby providing a basis for a better understanding of gene regulation in this important crop plant.

Result

To predict transcriptional enhancers in

SUBMITTER: Oka R 

PROVIDER: S-EPMC5522596 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature