Neuroimaging markers associated with maintenance of optimal memory performance in late-life.

ABSTRACT:

Background

Age-related memory decline has been well-documented; however, some individuals reach their 8th-10th decade while maintaining strong memory performance.

Objective

To determine which demographic and biomarker factors differentiated top memory performers (aged 75+, top 20% for memory) from their peers and whether top memory performance was maintained over 3 years.

Methods

Clinically normal adults (n=125, CDR=0; age: 79.5±3.57 years) from the Harvard Aging Brain Study underwent cognitive testing and neuroimaging (amyloid PET, MRI) at baseline and 3-year follow-up. Participants were grouped into Optimal (n=25) vs. Typical (n=100) performers using performance on 3 challenging memory measures. Non-parametric tests were used to compare groups.

Results

There

SUBMITTER: Dekhtyar M 

PROVIDER: S-EPMC5522601 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature